Wissenschaftliche Untersuchungen im Bereich L-Fucose

Zahlreiche wissenschaftliche Untersuchungen haben die Vorzüge und Funktionsweisen der L-Fucose bereits untersucht und diese sowohl in in-vivo als auch in in-vitro Studien nachgewiesen. Hier sind einige der wichtigsten und aussagekräftigsten wissenschaftlichen Publikationen aufgeführt, welche die Ergebnisse der wissenschaftlichen Forschungsarbeiten und Studien im Bereich der L-Fucose dokumentieren.

• Becker, D. J. and Lowe, J. B. (2003). Fucose: biosynthesis and biological function in mammals. Glycobiology 13(7): 41R–53R.
• Fodil-Bourahla, I., Bizbiz, L., Schoevaert, D. et al. (2003). Effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis. Biomed Pharmacother. 57(5-6):209-215.
• Gardiner, T. (2000). Dietary fucose: Absorption, distribution, metabolism, excretion (ADME) and biological activity. GlycoScience & Nutrition 1(6): 1-4.
• Hasegawa, S., Baba, T. and Hori, Y. (1980). Suppression of allergic contact dermatitis by a-L-fucose. J Invest Dermatol. 75:284-287.
• Isnard, N., Péterszegi, G., Robert, A.M. et al. (2002). Regulation of elastase-type endopeptidase activity, MMP-2 and MMP-9 expression and activation in human dermal fibroblasts by fucose and a fucose-rich polysaccharide. Biomed. Pharmacother. 56(5):258-264.
• Isnard, N., Fodil-Bourahla, I., Robert, A.M. and Robert, L. (2004). Pharmacology of sking aging. Stimulation of glycosaminoglycan biosynthesis by L-Fucose and Fucose-rich polysaccharides, effect of in vitro aging of fibroblasts. Biomedicine & Pharmacotherapy. 58:202-204.

• Matthies, H., Schroeder, H., Smalla, K.H. and Krug, M. (2000). Enhancement of Glutamate Release by L-Fucose Changes Effects of Glutamate Receptor Antagonists on Long-Term Potentiation in the Rat Hippocampus. Learn. Mem. 7: 227-234.
• Nemanic, M.K., Whitehead, J.S. and Elias, P.M. (1983). Alterations in membrane sugars during epidermal differentiation: visualization with lectins and role of glycosidases. The Histochemical Society. 31(7): 887-897.
• Péterszegi, G., Robert, A.M. and Robert, L. (2003). Protection by L-fucose and fucose-rich polysaccharides against ROS-produced cell death in presence of ascorbate. Biomed. Pharmacother. 57(3-4):130-133.
• Robert, L., Fodil-Bourahla, I., Bizbiz, L. et al. (2004). Effect of L-fucose and fucose-rich polysaccharides on elastin biosynthesis, in vivo and in vitro. Biomed Pharmacother 58(2):123-128.
• Robert, C., Robert, A.M., Robert, L. (2005). Effect of a preparation containing a fucose-rich polysaccharide on periorbital wrinkles of human voluntaries. Skin Res Technol. 2005 Feb;11(1):47-52.
• Robert, L., Molinari, J., Ravelojaona, V., Andrès, E. and Robert, A.M. (2009). Age- and passage-dependent upregulation of fibroblast elastase-type endopeptidase activity. Role of advanced glycytion endproducts, inhibition by Fucose- and rhamnose-riche oligosaccharides. Arch Gerontol Geriatr. Jun. 25, 2009.
• Vanhooren, P. T. and Vandamme, E. J. (1999). Fucose: Occurrence, physiological role, chemical, enzymatic and microbial synthesis. J. Chem. Technol. Biotechnol 74(6):479-497.