Wissenschaftliche Untersuchungen im Bereich Fucosyllactose

Zahlreiche wissenschaftliche Untersuchungen haben die Vorzüge und Funktionsweisen der Fucosyllactosen und hier insbesondere in der Säuglingsernährung und in dem Bereich der menschlichen Immunabwehr untersucht und beschrieben. Hier sind einige der zentralen und aussagekräftigsten wissenschaftlichen Publikationen aufgeführt.


Referenzen

• Andersson, B., O. Porras, L. A. Hanson, T. Lagergard, and C. Svanborg-Eden (1986). Inhibition of attachment of Streptococcus pneumoniae and Haemophilus influenzae by human milk and receptor oligosaccharides. J Infect Dis 153:232-7.
• Ashida, H., A. Miyake, M. Kiyohara, J. Wada, E. Yoshida, H. Kumagai, T. Katayama, and K. Yamamoto (2009). Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates. Glycobiology.
• Boehm, G., and B. Stahl (2007). Oligosaccharides from milk. J Nutr 137:847S-9S.
• Coppa, G. V., S. Bruni, L. Morelli, S. Soldi, and O. Gabrielli (2004). The first prebiotics in humans: human milk oligosaccharides. J Clin Gastroenterol 38:S80-3.
• Coppa, G. V., L. Zampini, T. Galeazzi, B. Facinelli, L. Ferrante, R. Capretti, and G. Orazio (2006). Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris. Pediatr Res 59:377-82.
• Crane, J. K., S. S. Azar, A. Stam, and D. S. Newburg (1994). Oligosaccharides from human milk block binding and activity of the Escherichia coli heat-stable enterotoxin (STa) in T84 intestinal cells. J Nutr 124:2358-64

• Harmsen, H. J., A. C. Wildeboer-Veloo, G. C. Raangs, A. A. Wagendorp, N. Klijn, J. G. Bindels, and G. W. Welling (2000). Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 30:61-7.
• Huang, P., T. Farkas, W. Zhong, M. Tan, S. Thornton, A. L. Morrow, and X. Jiang (2005). Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns. J Virol 79:6714-22.
• Kunz, C., Rudolff, S. (2006). Health promoting aspects of milk oligosaccharides. International Dairy Journal 16(11): 1341-1346.
• Morrow, A. L., G. M. Ruiz-Palacios, M. Altaye, X. Jiang, M. L. Guerrero, J. K. Meinzen-Derr, T. Farkas, P. Chaturvedi, L. K. Pickering, and D. S. Newburg (2004). Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. J Pediatr 145:297-303.
• Newburg, D. S. (2000). Oligosaccharides in human milk and bacterial colonization. J Pediatr Gastroenterol Nutr 30 Suppl 2:S8-17.
• Newburg, D. S., G. M. Ruiz-Palacios, and A. L. Morrow (2005). Human milk glycans protect infants against enteric pathogens. Annu Rev Nutr 25:37-58.
• Sharon, N., and H. Lis (1993). Carbohydrates in cell recognition. Sci Am 268:82-9.
• Ward, R. E., M. Ninonuevo, D. A. Mills, C. B. Lebrilla, and J. B. German (2006). In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri. Appl Environ Microbiol 72:4497-9.
• Yoshioka, H., K. Iseki, and K. Fujita (1983). Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants. Pediatrics 72:317-21.
• Zopf, D., and S. Roth (1996). Oligosaccharide anti-infective agents. Lancet 347:1017-21.