Complex Oligo- and Mono-saccharides - Key to New Pharmaceuticals and Diagnostics

Sugars like oligo- and polysaccharides, the so called glycans, are not only an essential source of energy for the human organism, but do also represent the largest and most diverse group of biopolymers. Glycobiology - the exploration of the structural and functional diversity of glycans - has become one of the most important and promising field of research in natural science. The development of new analytical methods for clinical diagnostics and of novel therapeutic approaches for the prevention and treatment of diseases are made possible by the rapid increase of the level of knowledge in the field of glycobiology.



In the human body glycans are present either in free state (unbound) or as glycoconjugates, which consist of sugar chains linked to proteins (glycoproteins) or lipids (glycolipids). These glycoconjugates can be found at the surface of nearly all cells and do play an important role in the process of molecular recognition. In this process glycoconjugates are not only of central importance in the recognition of human cells among each other but also in the interaction of the eukaryotic cell with microorganisms, viruses or toxins. Various pathogenic microorganisms such as Haemophilus influenzae, Vibrio cholerae or Salmonella strains, but also viral germs like HI- and noro-viruses, for example, bind to the sugar residues and thus infect the human body. Hence, there exists great and growing interest in the development of therapeutics that interfere, modulate or exploit the glycan-based host-pathogen-interaction.

A further field of glycobiology is the development of therapeutics for the treatment of various diseases. An abnormal glycosylation of cells, for example, is a marker for certain cancer types. Moreover, chronic inflammatory intestinal diseases like Morbus Crohn, Colitis ulcerosa, as well as IgA nephropathy are disorders, which make the development of glycan therapeutics look very promising. Moreover, glycan-structures do play an essential role in the "normal development" of the human organism and her in particular in the development of the nervous system.




Distribution of the Products of Jennewein Biotechnologie GmbH for the Use in Research & Development as well as Diagnostics

The advantage of Jennewein Biotechnologie GmbH in the production of the products L-Fucose, GDP-Fucose as well as CMP-sialic acid lies in the use of innovative and efficient production processes. These processes allow Jennewein Biotechnologie GmbH to offer the products to extremely attractive prices and in scalable quantities. By doing so, the use of the molecules becomes possible in new fields of application because of economic reasons as well as due to the quantities available.

The products L-Fucose, GDP-Fucose and CMP-sialic acid for the use in research & development activities as well as diagnostics can be ordered directly by Jennewein Biotechnology GmbH. In case of interest we are happy to reply to your query and to provide you our list of prices for the respective products as well as sales conditions.

In addition, Jennewein Biotechnologie GmbH co-operates with established distributors in the field of laboratory reagents. In case of interest we can provide you with information to our distribution partners in your local market.